Abstract Search

ea0007p32 | Cytokines and growth factors | BES2004

Urinary human chorionic gonadotrophin (hCG) associated proteins: isolation and characterisation by peptide identification mass spectrometry

Iles R , Malatos S , Butler S , Neubert H , Kicman A

Proteins associated with pregnancy urine and urinary-derived hCG preparations have been associated with stimulation of Candida albicans, induction of apoptosis in Kaposi's sarcoma, and inhibition of HIV replication. The active components have been previously reported to be 18 kDa, 15-30 kDa and 2-4 kDa proteins, and suggested in one study to be a ribonuclease (1).The urinary hCG preparation CG-10 (supplied by Sigma Chemical Company Ltd) is known to be pa...

0 shares

ea0007p195 | Reproduction | BES2004

Analysis of hCG beta core fragment glycosylation in normal and aberrant pregnancy by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry

Malatos S , Jacoby E , Juneja N , Butler S , Kicman A , Iles R

Metabolism of the dimeric glycoprotein hormone human chorionic gonadotrophin (hCG) results in the urinary excretion of hCG beta core fragment originating from the beta subunit of hCG (hCGbeta). hCG beta core fragmant retains a certain antigenic shape as well as two metabolically processed N-linked oligosaccharides. Hyperglycosylation of hCGbeta has been used as an indication of aberrant pregnancy especially in malignant disease. We have previously characterised the carbohydrat...

0 shares

Endocrine Abstracts

Urinary human chorionic gonadotrophin (hCG) associated proteins: isolation and characterisation by peptide identification mass spectrometry

Analysis of hCG beta core fragment glycosylation in normal and aberrant pregnancy by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry

BiosciAbstracts